«Innovative methods of synthesis and technologies for producing functional inorganic and organic substances and materials from natural and technogenic raw materials» (BR18574042) Priority and specialized scientific field. Fundamental and applied research. Field and type of research. Scientific research in the field of natural sciences. Fundamental and applied research in the field of chemistry. Implementation period: January 2023 – until November 01, 2024 The purpose of the program: to create the physical and chemical foundations for obtaining domestic environmentally friendly synthetic inorganic, organic substances and complex polymer materials for industry, agriculture and medicine Relevance. Research work under the Program is aimed at increasing the scientific potential of inorganic, organic, polymer, analytical, environmental chemistry, chemistry of biologically active compounds and related sciences, as well as chemical technology. The applied significance of the program lies in the creation of new effective substances and materials for multipurpose use to reduce import dependence on medicines, mineral fertilizers and their modifiers, effective catalytic systems for the synthesis of olefinic hydrocarbons from alternative petroleum raw materials for the production of petrochemical products, polymer materials and composites used in technologies for the restoration of contaminated and disturbed lands, treatment of industrial wastewater, selective extraction of ions of noble and rare metals, ultimately leading to increased food security of the country and improved environmental situation. Expected results for 2023. Development of technological foundations for creating methods for the synthesis of new polymer, inorganic, organic substances and materials for multipurpose use for the Republic of Kazakhstan, as well as scientific and scientific-practical foundations for the synthesis and justification of optimal parameters for obtaining energy-resource-saving, low-waste technology of polyfunctional materials for improving the environmental situation, development of innovative technologies for the complex processing of natural, phytoraw materials and technogenic waste into highly effective import-substituting adsorbents, fertilizers and composite materials; Achievements for 2023: -the regularities of the influence of the nature of the additive on the anticorrosion properties of dihydromonophosphate and potassium polyphosphate in various media, on the process of obtaining organomineral composite mixtures obtained by chemical modification of sodium humate with dihydro- and orthophosphates of aluminum, were revealed. The conditions and parameters of the process of obtaining phosphorus-containing mixtures with a high degree of metal protection and organomineral composite materials have been optimized; -the chemical interaction in the three-component water-salt system dimethylolurea – molybdenum phytocomponent – water was studied. The crystallization region of a new double compound – the active substance based on DMM and FSMo, at a molar ratio of 4:1, has been established. In model soil samples, the effect of the active substance on the number of soil microorganisms and the accumulation of mobile forms of nitrogen was studied. The stability was studied and the optimal storage periods of the preparative form of the composition based on 4DMM•FSMo were determined depending on the pH and temperature values (pH 5.4 and temperature 20оС 3 months; pH 6.5 and temperature 20оС 3 months, temperature 35 оС 6 months; pH 7.5 and temperature 20оС 3 months, temperature 35 оС 6 months); -the optimal conditions for the synthesis of a new phosphorus-containing sorbent based on modified natural mineral raw materials (vermiculite, zeolite), glycidyl methacrylate and orthophosphoric acid at a ratio of initial components (zeolite-GMA-H3PO4, vermiculite-GMA-H3PO4) – 1.0:1.0 were determined. It was shown that the chemical resistance of the cation exchanger based on vermiculite-GMA-H3PO4 in aggressive media is reduced to 4-8%. The surface structure was studied using a scanning electron microscope. The elemental composition of the cation exchanger vermiculite-GMA-H3PO4 contains 16.69% carbon, 31.55% oxygen, and also contains the elements Mg 4.21%, Al 4.81%, Si 16.55%, K 2.13%, Fe 13.66%; - the optimal conditions for the synthesis of modified natural mineral raw materials (vermiculite, zeolite) with copolymers of glycidyl methacrylate and orthophosphoric acid by the microwave method were determined (zeolite-GMA-H3PO4, vermiculite-GMA-H3PO4 – 1.0:1.0). The SEC of the sorbent was 3.92 mg-eq/g for zeolite-GMA-H3PO4 and 3.55 mg-eq/g for vermiculite-GMA-H3PO4 in 0.1 N HCl solution. It was established that the optimal conditions for the synthesis of a redox polymer based on the Purolite A-103 anion exchanger and 1,4-naphthoquinone are a molar ratio of 1:0.2; solvent–ethanol; catalyst–25% ammonia solution, temperature – 78.7 °С, time – 30 min; - the effect of activation methods on the conformational, electrochemical and sorption properties of Lewatit CNP LF and AB-17-8 ion exchangers was studied, and the efficiency and effect of mutual activation of polymers in an aqueous medium on the sorption of scandium ions was investigated. The dynamics of sorption of scandium and lutetium ions by the interpolymer system "Lewatit CNP LF:АВ-17-8" (X:Y) were investigated. It was shown that the interpolymer system in a ratio of 5:1 can be used as an effective sorbent for scandium ions, and in a ratio of 4:2 – for the sorption of lutetium ions from aqueous systems; -the sorption activity of the interpolymer system "gPAK:gP4VP" and "KU-2-8:gP4VP" (X:Y) in relation to gold ions [AuCl4]- was studied. It was established that for the "gPAK:gP4VP" system, the maximum sorption activity is observed at a molar ratio of 5:1, and in the case of "KU-2-8:gP4VP" - at a ratio of 2:4;. - scientific and technical support was provided for the efficiency of methods for the synthesis of hetero- and organoelement compounds under ultrasonic and microwave activation. The synthesis of α-aminophosphonates was carried out in the three-component "one-pot" Kabachnik-Fields reaction (yield 71-92%), as well as under ultrasonic and microwave activation. Esters of 1-(2-ethoxyethyl)-4-(pentin1-yl)piperidin-4-ol were obtained by reaction with various acylating agents (yield 81.6-94.9%). Based on the secondary alcohol 1-(2-phenylethyl)-4-oxopiperidine, the reaction with benzoyl and 3-fluorobenzoyl chloride was studied, and based on 1-(2-phenylethyl)-4-ethynyl-4-hydroxypiperidine with 2- and 4-fluorobenzoyl chloride. The biological activity of 1-(2-phenylethyl)-4-(m-fluorobenzoyloxy) piperidine hydrochloride (MA-5), 1-(2-phenylethyl)-4-cyclohexanecarbonyloxypiperidine hydrochloride (MA-10) on antimicrobial activity in in vitro experiments was studied. It was shown that in relation to the test strains Staphylococcus aureus ATCC 6538-Р and Escherichia coli ATCC 8739, the effectiveness of the drug MA-5 is 2 times higher, and the compound MA-10 is 5 times higher than the effect of the comparison drug ampicillin. In relation to yeast-like fungi of the genus Candida albicans ATCC 10231, for samples MA-5 and MA-10, the minimum fungicidal concentration was 1000 μg/ml, and in relation to Aspergillus brasiliensis ATCC 16404, the minimum bactericidal concentration was – 125 μg/ml. Hydrochloride, acetate, oxalate and citrate were obtained on the basis of O-para-toluoyl-β-(morpholine-1-yl)propioamidoxime. The in vitro antimycobacterial screening on M. bovis mycobacteria revealed high activity of salts, which had a minimum inhibitory concentration MIC equal to 0.1 μg/ml. Tests for antimicrobial activity on Staphylococcus aureus, Escherichia coli and Salmonella gallinarum bacteria showed no activity; -catalytic systems were studied by modifying natural and synthetic zeolites. The synthesis of lower olefins from a mixture of light alkanes was carried out by their dehydrogenation on a 1.0 % Rh/ZSM-5 catalyst, which allows selective production of lower olefins. Under optimal conditions, the total yield of ethylene and propylene is 20.4%. The process of synthesis of higher olefins by catalytic cracking of paraffinic hydrocarbons was studied, using a heteropolyacid-synthetic zeolite type ZSM-5 system as a catalyst. The maximum yield of liquid products on the 10% PW12-GPA/ZSM-5 catalyst is observed at a temperature of 550°C and is 53.9 %. The conversion of paraffin is 93 %, while the selectivity for liquid cracking products reaches 58 %. At a temperature of 550°C, the amount of higher olefins (including linear α-olefins) in the liquid fraction is the largest and amounts to 37.2%. In addition to them, aromatic (37.7%) and naphthenic hydrocarbons (9.6%) are formed, the remaining alkanes and isoalkanes (25.5%).; - the reactivity of 1,5-di(prop-2-ynyloxy)naphthalene and 2,7-di(prop-2-ynyloxy)naphthalene under Mannich reaction conditions was studied, new bis(aminobutinyloxy)naphthalenes were synthesized. The acylation reaction of dithiocarbamates of heterocyclic amines (1H-benzo[d][1,2,3]triazole and dibenzylamine) was studied, new derivatives were synthesized by reaction with chlorides of 2-bromo-, 4-nitro-, 2,4-dichloro-, 4-chloro- and 4-fluorobenzoic acids; - objects and points (points) of observation, a list of controlled parameters, the frequency of measurements using physical and chemical methods of analysis were determined. The content of hydrocarbons and constituent groups of the organic part of oil-contaminated soils and oil sludge from the polygons of group installations (GU-57) was determined. GU-(85), NGDU-4 (oil and gas production department) JSC "Ozenmunaigas". Physical and chemical studies of industrial waste, OS components, using mass spectrometry, gas and liquid chromatography, gas analyzers, IR spectrometry, thermogravimetric analysis, atomic absorption spectrometry, X-ray fluorescence analysis, as well as combined research methods were carried out. Researchers F.I.O. Position ORCID identifier