World's First! 10,000 Tons! Straw-Based Succinic Acid Biosynthesis Production Line! Founded by Tsinghua, MIT, and Other Universities

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World's First! 10,000 Tons! Straw-Based Succinic Acid Biosynthesis Production Line! Founded by Tsinghua, MIT, and Other Universities

Fully biodegradable materials 2025-03-04 09:35:52

"Straw-derived bio-based 1, 4-butanediol" and "straw sugar biosynthesis."

The first product, non-grain biomass-based 1, 4-butanediol (BDO), and its hydrogenated derivative 1, 4-butanediol (BDO), are key platform materials for a series of strategic products including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw - cellulose sugar - engineered strains - succinic acid, the company has for the first time globally achieved a ten-thousand-ton level production line for straw-based succinic acid biosynthesis, solving the industrialization problem of straw, enhancing the competitiveness of bio-manufacturing, and providing more possibilities for the future large-scale development of non-grain biosynthesis.

As a key platform material for a series of strategic products, non-grain biomass-based 1, 4-butanediol will strongly promote green manufacturing across all downstream industries.

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01、Straw-derived Bio-based 1, 4-Butanediol (BDO) and 1, 4-Butanedicarboxylic Acid (Succinic Acid)

The first product, non-grain bio-based material 1, 4-butanedicarboxylic acid, along with its hydrogenated derivative 1, 4-butanediol (BDO), is a key platform raw material for a series of strategic products including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar to engineered strains to succinic acid, the company has achieved, for the first time globally, a ten-thousand-ton level production line for straw-based succinic acid biosynthesis. This solves the industrialization challenge of straw, enhances the competitiveness of biomanufacturing, and provides more possibilities for the future large-scale development of non-grain biosynthesis.

As a key platform raw material for a series of strategic products, non-grain bio-based 1, 4-butanedicarboxylic acid will powerfully promote green manufacturing in various downstream industries.

01, Lignocellulosic Biomass-derived 1, 4-Butanediol (BDO)

The first product, non-grain-based biobased material 1, 4-butanediol (BDO), and its hydrogenated derivative 1, 4-butanediol (BDO) are key platform raw materials for a series of strategic products, including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar, to engineered strains, and finally to succinic acid, the company has globally pioneered a ten-thousand-ton scale lignocellulosic biomass-based succinic acid biosynthesis production line for the first time. This achievement solves the challenge of industrializing straw, enhances the competitiveness of bio-manufacturing, and provides more possibilities for the future large-scale development of non-grain-based biosynthesis.

As a key platform raw material for a series of strategic products, non-grain-based biobased material 1, 4-butanediol (BDO) will significantly promote green manufacturing across various downstream industries.

01、Straw-derived Bio-based 1, 4-Butanedicarboxylic Acid (Succinic Acid)

The first product, non-grain bio-based material 1, 4-butanedicarboxylic acid (succinic acid), and its hydrogenated derivative 1, 4-butanediol (BDO), are key platform raw materials for a series of strategic products such as biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar to engineered strains to succinic acid, the company has globally pioneered the realization of a ten-thousand-ton scale production line for straw-based succinic acid biosynthesis, solving the industrialization challenge of straw and enhancing the competitiveness of bio-manufacturing. This provides more possibilities for the future large-scale development of non-grain bio-synthesis.

As a key platform raw material for a series of strategic products, non-grain bio-based 1, 4-butanedicarboxylic acid will strongly promote green manufacturing in various downstream industries.

01, Lignocellulosic Biomass-derived 1, 4-Butanediol (BDO)

The first product, non-grain-based bio-material 1, 4-butanediol (BDO), and its hydrogenation derivative 1, 4-butanediol (BDO) are key platform raw materials for a series of strategic products including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar, to engineered strains, to succinic acid, the company has for the first time globally achieved a ten-thousand-ton scale lignocellulosic biomass-based succinic acid biosynthesis production line. This solves the problem of industrializing straw and enhances the competitiveness of bio-manufacturing, providing more possibilities for the future large-scale development of non-grain-based biosynthesis.

As a key platform raw material for a series of strategic products, non-grain-based 1, 4-butanediol will strongly promote green manufacturing across various downstream industries.

01, Lignocellulosic Biomass-derived 1,4-Butanediol (BDO)

The first product, non-grain-based biobased material 1,4-butanediol (BDO), and its hydrogenated derivative 1,4-butanediol (BDO), are key platform raw materials for a series of strategic products including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar to engineered strains to succinic acid, the company has achieved the world's first ten-thousand-ton lignocellulose-based succinic acid biosynthesis production line, solving the industrialization challenges of straw and enhancing the competitiveness of bio-manufacturing, providing more possibilities for the future large-scale development of non-grain-based biosynthesis.

As a key platform raw material for a series of strategic products, non-grain-based biobased 1,4-butanediol will strongly promote green manufacturing across various downstream industries.

01, Biomass-based 1, 4-Butanediol from Straw Sources

The first product is non-grain biomass-based material 1, 4-butanediol (BDO), and its hydrogenated derivative 1, 4-butanediol (BDO). These are key platform raw materials for a series of strategic products including biodegradable plastics (PBS, PBAT), polyurethane, and spandex.

From straw to cellulose sugar to engineered strains to succinic acid, the company has globally pioneered the realization of a ten-thousand-ton level production line for biomass-based succinic acid derived from straw. This solves the problem of industrializing straw and enhances the competitiveness of bio-manufacturing, providing more possibilities for the future large-scale development of non-grain biomass synthesis.

As a key platform raw material for a series of strategic products, non-grain biomass-based 1, 4-butanediol will strongly promote green manufacturing across various downstream industries.

01, Biomass-based 1, 4-Butanediol from Straw

01, Biomass-based 1, 4-Butanediol from Straw01, Biomass-based 1, 4-Butanediol from Straw 注意：在原文中，“1, 4-丁二酸”被翻译为“1, 4-Butanediol”。实际上，正确的化学名称应为“1, 4-Butanediol”，但根据上下文，如果原意是指“1, 4-Butanedioic acid”（即顺丁烯二酸或马来酸），请告知以便更正。

The first product is non-grain bio-based material 1,4 butanedicarboxylic acid (succinic acid), and its hydrogenated derivative 1,4 butanediol (BDO). These are key platform raw materials for a series of strategic products including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar to engineered strains to succinic acid, the company has achieved the world's first ten-thousand-ton level straw-based succinic acid biosynthesis production line. This solves the industrialization challenge of straw and enhances the competitiveness of bio-manufacturing, providing more possibilities for the future large-scale development of non-grain biosynthesis.

As a key platform raw material for a series of strategic products, non-grain bio-based material 1,4 butanedicarboxylic acid will strongly promote green manufacturing in various downstream industries.

02, Flexible Production Platform for Straw Sugar Biosynthesis

Suzhou Juvye Biotechnology Co., Ltd., based on its agricultural synthetic biology technology, has built a globally leading flexible production platform for straw sugar biosynthesis. This platform uses crop straw as the raw material and, through the integration and innovation of multidisciplinary technologies, achieves full-chain production from straw pretreatment to high-value-added bio-based products, with high flexibility and scalability.

The first product is the non-grain biomass-based material 1,4 butanediol (BDO) and its hydrogenated derivative 1,4 butanediol. This molecule serves as a key platform raw material for a series of strategic products, including biodegradable plastics (PBS, PBAT), polyurethanes, and spandex.

From straw to cellulose sugar, then to engineered strains, and finally to succinic acid, the company has achieved the world's first ten-thousand-ton level bio-synthetic production line of straw-based succinic acid. This breakthrough addresses the challenge of industrializing straw, enhances the competitiveness of bio-manufacturing, and opens up more possibilities for the future large-scale development of non-grain biosynthesis.

As a key platform raw material for a series of strategic products, the non-grain biomass-based material 1,4 butanediol will strongly promote green manufacturing across various downstream industries.

02. Flexible Production Platform for Straw Sugar Biosynthesis

Suzhou Juweiyuanchuang Biotechnology Co., Ltd. has built a globally leading flexible production platform for straw sugar biosynthesis based on its agricultural synthetic biology technology. This platform uses crop straw as raw material, achieving full-chain production from straw pretreatment to high-value-added biobased products through the integration and innovation of multidisciplinary technologies, with high flexibility and scalability.

I. Technical Architecture and Core Advantages

1. Efficient Pretreatment and Saccharification Technology of Raw Materials

Juweiyuanchuang adopts clean separation technology for lignocellulosic tricomponents, efficiently separating cellulose, hemicellulose, and lignin in straw to provide high-purity raw materials for subsequent saccharification. Through AI artificial intelligence enzyme engineering, its cellulose saccharification rate exceeds 90%, significantly reducing production costs.

The platform also features a modular pretreatment system that can adapt to different types of straw (such as rice, wheat, corn, etc.), achieving broad raw material sources and process flexibility.

2. Metabolic Engineering and Multi-Product Flexible Production

Based on synthetic biology technology, Juweiyuanchuang has constructed programmable cell factories capable of directed synthesis of high-value platform molecules such as succinic acid, butanediol, butanediamine, and farnesene.

Multiproduct Compatibility: The same production line can produce multiple products including biobased materials, fine chemicals, and animal nutritional supplements by switching strains and metabolic pathways, meeting downstream market demands.

3. Scalable and Replicable Production Line Design

02, Flexible Production Platform for Biomass Sugar Biosynthesis

02, Flexible Production Platform for Biomass Sugar Biosynthesis02, Flexible Production Platform for Biomass Sugar Biosynthesis

Suzhou Juweiyuanchuang Biotechnology Co., Ltd. has built a globally leading flexible production platform for the biosynthesis of straw sugar based on its agricultural synthetic biology technology. This platform, using crop straw as raw material, achieves full-chain production from straw pretreatment to high-value-added biobased products through the integration and innovation of interdisciplinary technologies. It is highly flexible and scalable.

I. Technical Architecture and Core Advantages

1. Efficient Raw Material Pretreatment and Saccharification Technology

Juweiyuanchuang uses clean separation technology for lignocellulosic components, effectively separating cellulose, hemicellulose, and lignin in straw to provide high-purity raw materials for subsequent saccharification. Through AI-based enzyme engineering, its fiber saccharification rate exceeds 90%, significantly reducing production costs.

The platform also employs a modular pretreatment system that adapts to different types of straw (such as rice, wheat, and corn), achieving broad raw material sources and process flexibility.

2. Metabolic Engineering and Multi-product Flexible Production

Multi-product compatibility: The same production line can switch between strains and metabolic pathways to produce various products including biobased materials, fine chemicals, and animal nutrition, meeting downstream market demands.

3. Scalable and Replicable Production Line Design

The platform adopts a modular production line layout, which can be flexibly expanded according to capacity requirements.

A stepwise expansion model is adopted, providing a replicable commercial model for the global non-food biosynthesis industry.

II. Innovation Highlights and Industry Value

1. Zero-Carbon Raw Materials and Green Processes

By substituting traditional petroleum or food raw materials with straw, it can reduce carbon emissions by several hundred million tons per year

Suzhou Juweiyuanchuang Biotechnology Co., Ltd. has built a globally leading flexible production platform for the biosynthesis of straw sugar based on its agricultural synthetic biology technology. This platform uses crop straw as raw material and, through the integration and innovation of interdisciplinary technologies, achieves full-chain production from straw pretreatment to high-value-added biobased products, with high flexibility and scalability.

I. Technical Architecture and Core Advantages

1. Efficient Pretreatment and Saccharification Technology of Raw Materials

Juweiyuanchuang adopts clean separation technology for lignocellulose's three components, efficiently separating cellulose, hemicellulose, and lignin in straw to provide high-purity raw materials for subsequent saccharification. Through AI-based enzyme engineering, its fiber saccharification rate exceeds 90%, significantly reducing production costs.

The platform also utilizes a modular pretreatment system to adapt to different types of straw (such as rice, wheat, and corn), achieving broad raw material sources and process flexibility.

2. Metabolic Engineering and Multi-product Flexible Production

Based on synthetic biology technology, Juweiyuanchuang has built a programmable cell factory capable of synthesizing high-value platform molecules such as succinic acid, butanediol, butanediamine, and farnesene in a targeted manner.

Multiproduct Compatibility: The same production line can produce multiple types of products including biobased materials, fine chemicals, and animal nutrition products by switching strains and metabolic pathways, meeting the demands of downstream markets.

3. Scalable and Replicable Production Line Design

The platform adopts a modular production line layout that can be flexibly expanded according to capacity requirements.

A stepwise expansion model is adopted, providing a replicable commercial template for the global non-grain biosynthesis industry.

II. Innovation Highlights and Industry Value

1. Zero-carbon Raw Materials and Green Processes

Replacing traditional petroleum or grain raw materials with straw can reduce carbon emissions by several hundred million tons annually, aligning with the "dual carbon" strategy.

2. Intelligent and Digital Management

The platform integrates Internet of Things (IoT) and AI technologies to monitor fermentation parameters in real time, optimize enzymatic efficiency, and predict equipment maintenance cycles through big data analysis, ensuring continuous and stable production.

3. Industry Chain Collaboration and Commercialization

Juweiyuanchuang collaborates deeply with leading downstream enterprises to promote the application of straw-based chemicals in the field of biobased materials.

In addition, the platform technology has covered multiple fields including bio-based materials, animal nutrition, and industrial enzymes, forming a "multi-use from one source" model. This industrial ecosystem is centered around "zero-carbon raw materials + intelligent processes + multi-product output."

PolyWeaver's flexible production platform for straw sugar biosynthesis not only addresses the bottleneck of traditional biosynthesis relying on food raw materials but also achieves low-cost, high-efficiency large-scale production through modular and digital design. This platform is not only a model for the high-value utilization of agricultural waste but also provides a replicable technical pathway and commercial benchmark for the green transformation of the global synthetic biology industry.

03, Company Profile

Suzhou Juweiyuanchuang Biotechnology Co., Ltd. is dedicated to using straw as raw material and employing biosynthesis methods to produce chemical molecular products. The founding team of the company comes from prestigious institutions such as Tsinghua University and Massachusetts Institute of Technology, possessing full-chain self-research and production capabilities.

The team has accumulated a large number of research and development achievements in disciplines such as genetic engineering, metabolic engineering, biochemical engineering, and polymer materials and engineering. The company has established a multidisciplinary professional technology and process R&D team, successively building non-model industrial chassis cell libraries, efficient gene editing, AI protein screening, and modification, among other cutting-edge technology platforms. It has pioneered internationally a commercially viable technical route for straw saccharification and biosynthesis.

The company's headquarters and R&D center are located in Suzhou, with 100,000-ton level production bases built in Lianyungang, Jiangsu, Liaocheng, Shandong, and other places, striving to promote the innovative development of non-grain biomanufacturing industry.

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World's First! 10,000 Tons! Straw-Based Succinic Acid Biosynthesis Production Line! Founded by Tsinghua, MIT, and Other Universities

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